Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1 Muscle-specific Knock-out Animals*
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چکیده
Christoph Handschin, Sherry Chin, Ping Li, Fenfen Liu , Eleftheria Maratos-Flier , Nathan K. LeBrasseur**, Zhen Yan, and Bruce M. Spiegelman From the Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27704, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, and **Diabetes and Metabolism Unit, Boston University School of Medicine, Boston, Massachusetts 02118
منابع مشابه
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals.
The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is a key integrator of neuromuscular activity in skeletal muscle. Ectopic expression of PGC-1alpha in muscle results in increased mitochondrial number and function as well as an increase in oxidative, fatigue-resistant muscle fibers. Whole body PGC-1alpha knock-out mice have a very c...
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Individual skeletal muscles in the animal body are heterogeneous, as each is comprised of different fiber types. Type I muscle fibers are rich with mitochondria, and have high oxidative metabolisms while type IIB fibers have few mitochondria and high glycolytic metabolic capacity. Peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), a transcriptional co-activator that regul...
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تاریخ انتشار 2007